ProVate Supports:
A novel option for the
self-management of
pelvic organ prolapse

ProVate Supports:
A novel option for the
self-management of
pelvic organ prolapse
ProVate Supports:
A novel option for the self-management of pelvic organ prolapse
ProVate Supports:
A novel option for the
self-management of
pelvic organ prolapse
What is ProVate?
The ProVate Device is a single-use vaginal support for the temporary, nonsurgical management of pelvic organ prolapse in women. Each ProVate device is intended to be used for up to 7 days. ProVate works for various types of prolapse by holding pelvic organs in their normal positions.
ProVate is available by prescription only after an initial fitting and use training by a qualified health care provider. Talk to your doctor with questions and to see if ProVate is right for you. Individual results may vary.
Convenient
ProVate is not dependent on office visits for routine insertion and removal. Users can insert and remove the support on their own for any reason.
User-friendly
ProVate comes ready for use in a disposable tampon-like applicator and has an attached string for convenient removal.
Disposable
ProVate Supports are thrown away in the trash upon removal, with no need to clean or store used supports.
Pelvic organ prolapse, also known as POP, is a condition where the tissue and the muscles of the pelvic floor no longer support the pelvic organs. Approximately 50 percent of women will develop POP.
Why ProVate?
For women diagnosed with POP by their health care provider, ProVate offers a disposable self-managed treatment option that may integrate easily into their daily routine. ProVate collapses down to a smaller size for convenient insertion and removal. Unlike traditional pessaries, ProVate gives women the power to manage POP on their own terms.
Talk to your doctor with questions and to see if ProVate is right for you.
ProVate | Pessaries* | |
Insertion with a tampon-like applicator | ✓ | |
Removal with attached string | ✓ | |
Disposable, one-time use | ✓ | |
Ability to remove at any time for any reason | ✓ | sometimes |
Patient-controlled at-home removal and insertion | ✓ | sometimes |
Initially sized and fitted by a health care provider | ✓ | ✓ |
Supports descending organ | ✓ | ✓ |
*Of pessaries available on the market as of October 2024.
Women should not use ProVate if they:
- Are under the age of 21
- Are pregnant or suspect that they are pregnant
- Had vaginal surgery within the past 3 months
- Had unusual or unexpected vaginal bleeding within the last 6 months
- Have been diagnosed with a severely dry and weakened (atrophic) vagina
- Have been diagnosed with a vaginal infection or a symptomatic urinary tract infection
- Currently have vaginal wall trauma (eg, laceration or mesh erosion)
In a clinical study
100% of patients who completed the study experienced significant prolapse reduction.
The primary objective of this study was to see how many women saw at least a 1-stage reduction in their prolapse following the use of ProVate, as ranked on the Pelvic Organ Prolapse Quantification (POP-Q)† score. 100 percent of the women who completed the study had at least 1 stage reduction at their fifth visit to their provider. 88 percent of all women who started the study had at least 1 stage reduction while using ProVate.
87.8% of women reported the highest level of satisfaction with the device.
92.9% reported that the device was
“very easy to use.”
Study design:
- A study of 47 women who used ProVate Supports at home and recorded how they felt their prolapse had improved.
Their prolapse was also measured in office by their provider throughout the study - 41 patients who used ProVate for 28-45 days completed the study
- Side effects were recorded in a daily diary
A total of 33 occurrences of side effects were seen during the study; 21 of these occurrences were ProVate device related.
- All potentially device-related side effects were mild, and all resolved on their own
- The most common side effects (reported by >1 woman) included: spotting, discomfort, pain, and vaginal burning
†The POP-Q system is a scale used to measure and classify the severity of POP. A physical exam is performed by a health care provider to measure the position of the pelvic organs. The POP-Q system uses a scale of 0 to 4, with 0 meaning no organ displacement and 4 meaning a complete prolapse.

Before ProVate was developed, few advancements had been made in the POP treatment space.
ProVate was selected as one of the best novel therapies by the American Urogynecologic Society.‡
‡In 2017.
How does ProVate work?
ProVate works by supporting the vaginal walls and holding the pelvic organs in place.
- ProVate comes in 6 sizes to accommodate as many patients as possible
- The device comes ready for use within a disposable applicator, which allows for a smooth and relatively comfortable insertion into the vagina
- Patients can keep ProVate in for up to 7 days, but it can be removed at any time before 7 days for any reason

The ProVate Support is inserted into the vagina in a slender oval shape with an applicator, for comfortable insertion.

When the applicator is in the vagina, the user will need to press the plunger of the applicator, similar to how she would insert a tampon.

The ProVate Support expands into a ring shape to support the vaginal walls.

The applicator is removed and disposed of.

When it is time to remove the ProVate Support, the string is pulled to collapse the support into a smaller size, which is then removed and thrown away in the trash.
Always follow the advice of your health care provider; be sure to ask questions to see if ProVate is right for you.
How do I get a ProVate prescription?
If you have been diagnosed with POP and are interested in ProVate as a potential treatment option, make an appointment with a qualified health care provider to see if ProVate may be right for you.
1. Vaginal digital size assessment of pessary ring
2. Provider inserts the appropriate ProVate size into the vagina and assesses adequacy
3. If needed – a larger or a smaller size may be used

Initial appointment and sizing by your doctor

At-home trial
1. Patient inserts a ProVate device into her vagina and also removes the device
2. Patient inserts another ProVate device into the vagina and goes home with a device in-situ

Follow up and getting a prescription
After the appropriate size of ProVate is confirmed, the prescription will be sent directly to Eagle Pharmacy, our specialty pharmacy. ProVate is available for direct shipping to your home.
Talk to your doctor with questions and to see if ProVate is right for you. Individual results may vary.
It is important to remember that it may take more than 1 visit to determine the appropriate size. It may be necessary to return multiple times for resizing.
Please note that some patients cannot retain a pessary at all due to the severity of their prolapse. It may take several trials of various sizes to arrive at this conclusion.
FAQs about pelvic organ prolapse
Symptoms of POP include, among others, feeling a lump within or outside the vagina, discharge, bleeding, constant pelvic heaviness, back pain, and difficulty going to the bathroom. If you have any of these symptoms, you should be examined by your health care provider.
Talk to your doctor with questions and to see if ProVate is right for you. Individual results may vary.
Approximately 50 percent of women will develop POP over their lifetimes. Not all women with POP experience symptoms, and some women only find out that they have POP after their doctor performs a pelvic exam.
POP can be caused by pregnancy, childbirth, menopause, or may simply develop over time.
POP can be diagnosed by an obstetrician/gynecologist or urogynecologist.
Conventionally, there have been 2 main treatment options for POP: traditional pessaries or surgery. You should discuss treatment options with your health care provider.
While many types of health care providers can diagnose POP, treatment for POP is often managed by obstetricians/gynecologists, urogynecologists, and urologists.
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